Carcinoma data
Table of Contents
Description
Data from a clinical trial conducted by the Radiation Therapy Oncology Group in the U.S. to investigate treatments of carcinoma of the oropharynx. Patients were recruited between 1968 and 1972 and randomized to either a standard radiotherapy treatment or an experimental treatment in which the radiotherapy was supplemented by chemotherapy. The main endpoint was patient survival and patients were followed until around the end of 1973. Several baseline covariates, thought to have strong prognostic value, were also recorded.
Variables
| Variable | Explanation (Unit) |
|---|---|
| id | patient id |
| inst | participating institution (1,2,3,4,5 or 6) |
| sex | 1=male, 2=female |
| trt | 0= experimental, 1= standard |
| grade | 1=well differentiated, 2=moderately differentiated. 3=poorly differentiated |
| age | age in years at time of diagnosis |
| cond | initial condition, 1= no disability, 2= restricted work, 3= require assistance with self care, 4= bed confined |
| site | tumor site 1= fausial arch, 2= tonsillar fossa, 4= pharyngeal tongue |
| T | T-staging: 1=primary tumor < 2 cm in largest diameter, 2=primary tumor 2 to 4 cm in largest diameter, minimal infiltration in depth, 3=primary tumor > 4 cm, 4=massive invasive tumor. |
| N | N-staging: 0= no clinical evidence of node metastases, 1= single positive node < 3cm in diameter, not fixed, 2= single positive node > 3cm in diameter, not fixed, 3=multiple positive nodes or fixed positive nodes |
| status | 1=death, 0= alive at end of follow-up (censored) |
| time | time from inclusion to death or end of follow-up (days) |
| dateEntry | date of inclusion |
Data download
| Format | Download |
|---|---|
| text (csv) | carcinoma.csv |
| rda (for R) | carcinoma.rda |
Load data into R
load(url("http://paulblanche.com/files/carcinoma.rda")) head(carcinoma)
References
Kalbfleisch and Prentice, The statistical analysis of failure time data, 2002. (see Appendix II)
Jennison and Turnbull. Group sequential methods with applications to clinical trials. CRC Press, 1999. (see Chapter 13)